Como calcular o equilíbrio de Hardy-weinberg para o ensino de polimorfismos genéticos? Uma planilha facilitadora para aula remota de biologia molecular

Autores

  • Howard Lopes Ribeiro Junior Postgraduate Program in Translational Medicine, Center for Research and Drug Development (NPDM), Federal University of Ceara, Fortaleza, Ceara, Brazil. Postgraduate Program of Pathology, Federal University of Ceara, Fortaleza, Ceara, Brazil. https://orcid.org/0000-0003-2431-4779
  • João Vitor Caetano Goes Post-Graduate Program of Pathology, Federal University of Ceara - CE. Post-Graduate Program in Translational Medicine, Federal University of Ceara - CE. Center for Research and Drug Development (NPDM), Federal University of Ceara - CE.

DOI:

https://doi.org/10.16923/reb.v20i2.959

Palavras-chave:

Aula prática, software educacional

Resumo

Este artigo descreve uma planilha de autopreenchimento completa para o cálculo de Hardy-Weinberg Equilibrium (HWE) para facilitar a compreensão da importância do cálculo de HWE para pesquisa experimental sobre análise de polimorfismo em uma classe remota de biologia molecular durante o período pandêmico do Coronavirus 2019 (COVID-19).

Referências

Bogoch II, Watts A, Thomas-Bachli A, et al. Potential for global spread of a novel coronavirus from China. J Travel Med. 2020; 27(2):taaa011.

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Delanghe JR, Speeckaert MM, De Buyzere ML. ACE Ins/Del genetic polymorphism and epidemiological findings in COVID-19. Clin Chem Lab Med. 2020;58(7):1129-1130.

Hardy GH. Mendelian proportions in a mixed population. Science. 1908; 28: 49-50.

Weinberg W. Über den Nachweis der Vererbung beim Menschen. Jahreshefte des Vereins für vaterländische Naturkunde in Württemberg. 1908; 64: 368–382.

Smith UM, Baldwim JT. Making Sense of Hardy-Weinberg Equilibrium. The American Biology Teacher (2015) 77 (8): 577–582.

Hartl DL, Clarke AG (2007). Principles of population genetics. Sunderland, MA: Sinauer. 2007.

Pierce, B. A. Genetics: A conceptual approach. New York: W.H. Freeman.

Ribeiro HL Jr, de Oliveira RT, Maia AR, et al. Polymorphisms of DNA repair genes are related to the pathogenesis of myelodysplastic syndrome. Hematol Oncol. 2015;33(4):220-228.

Khoury MJ, Little J, Burke W: Human genome epidemiology. a scientific foundation for using genetic information to improve health and prevent disease. New York: Oxford University Press, 2004.

Anwar YAS, Senam S, Laksono EW. The use of orientation / decision / do / discuss / reflect (OD3R) method to increase critical thinking skill and practical skill in biochemistry learning. Biochem Mol Biol Educ. 2018;46:107-113.

Silverstein TP. CoViD-19 epidemic follows the "kinetics" of enzymes with cooperative substrate binding [published online ahead of print, 2020 Jun 30]. Biochem Mol Biol Educ.

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Publicado

02-12-2022

Como Citar

Ribeiro Junior, H. L., & Goes, J. V. C. (2022). Como calcular o equilíbrio de Hardy-weinberg para o ensino de polimorfismos genéticos? Uma planilha facilitadora para aula remota de biologia molecular. Revista De Ensino De Bioquímica, 20(2), 322–328. https://doi.org/10.16923/reb.v20i2.959

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Inovações educacionais

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